65 research outputs found
GP-NAS-ensemble: a model for NAS Performance Prediction
It is of great significance to estimate the performance of a given model
architecture without training in the application of Neural Architecture Search
(NAS) as it may take a lot of time to evaluate the performance of an
architecture. In this paper, a novel NAS framework called GP-NAS-ensemble is
proposed to predict the performance of a neural network architecture with a
small training dataset. We make several improvements on the GP-NAS model to
make it share the advantage of ensemble learning methods. Our method ranks
second in the CVPR2022 second lightweight NAS challenge performance prediction
track
Wavelength dependence of electron localization in the laser-driven dissociation of H
We theoretically investigate the laser wavelength dependence of asymmetric
dissociation of H. It is found that the electron localization in
molecular dissociation is significantly manipulated by varying the wavelength
of the driving field. Through creating a strong nuclear vibration in the
laser-molecular interaction, our simulations demonstrate that the few-cycle
mid-infrared pulse can effectively localize the electron at one of the
dissociating nuclei with weak ionization. Moreover, we show that the observed
phase-shift of the dissociation asymmetry is attributed to the different
population transfers by the remaining fields after the internuclear distances
reach the one-photon coupling point.Comment: 11 pages, 7 figure
Postoperative ctDNA detection predicts relapse but has limited effects in guiding adjuvant therapy in resectable stage I NSCLC
BackgroundTo date, identifying resectable stage I non-small cell lung cancer (NSCLC) patients likely to benefit from adjuvant therapy (ADT) remains a major challenge. Previous studies suggest that circulating tumor DNA (ctDNA) is emerging as a promising biomarker for NSCLC. However, the effectiveness of ctDNA detection in guiding ADT for resectable stage I NSCLC patients remains elusive. This study aimed to elucidate the role of ctDNA detection in estimating prognosis and guiding ADT for resectable stage I NSCLC patients.MethodsIndividual patient data and ctDNA results data were collected from 270 patients across four independent cohorts. The detection of ctDNA was conducted at 3 days to 1 month after surgery. The endpoint for this study was relapse-free survival (RFS) and overall survival (OS).ResultsOf the 270 resectable stage I NSCLC patients, 9 patients with ctDNA-positive and 261 patients with ctDNA-negative. We found that the risk of recurrence was significantly lower in the ctDNA-negative group compared to the ctDNA-positive group(HR=0.11, p<0.0001). However, there is no difference in the risk of death between the two groups (p =0.39). In the ctDNA-positive group, there were no significant differences in RFS between patients who received ADT and patients who did not receive ADT (p =0.58). In the ctDNA-negative group, those who received ADT had a worse RFS in comparison with those who did not receive ADT (HR=2.36, p =0.029). No difference in OS was seen between patients who received ADT and patients who did not receive ADT in both the ctDNA-positive group and the ctDNA-negative group (All p values>0.05). Furthermore, there was no difference in RFS and OS between patients who received chemotherapy-based or tyrosine kinase inhibitor-based ADT and patients who did not receive ADT in both the ctDNA-positive group and the ctDNA-negative group (All p values>0.05).ConclusionsPostoperative ctDNA detection can be a prognostic marker to predict recurrence but has limited effects in guiding ADT for resectable stage I NSCLC. Future prospective investigations are needed to verify these results
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